Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)

Base Information

Chemical Name:Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)
CAS No.:288848-36-2
Molecular Formula:C9H14 O2
Molecular Weight:154.20626
Hs Code.:
Mol file:288848-36-2.mol

Synonyms:Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)

Suppliers and Price of Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)

Chemical Property:

PSA：34.14000
LogP:1.43660

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI)

There total 5 articles about Cyclobutaneacetaldehyde, 3-formyl-2,2-dimethyl-, (1R,3R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 288848-30-6
(1'R,3'R)-2-(3'-hydroxymethyl-2',2'-dimethylcyclobutyl)-1-ethanol

: 288848-36-2,552810-14-7
(1'R,3'R)-2-(3'-formyl-2',2'-dimethylcyclobutyl)acetaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -50 - 20 ℃;
DOI:10.1021/jo991773c

Reference yield:

: 473-72-3,17879-35-5,61376-92-9,61826-55-9,64396-97-0,127062-09-3,52305-34-7
(1'R,3'R)-2-(3'-acetyl-2',2'-dimethylcyclobutyl)acetic acid

: 288848-36-2,552810-14-7
(1'R,3'R)-2-(3'-formyl-2',2'-dimethylcyclobutyl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / aq. NaOBr / dioxane / 0 - 20 °C

2: 96 percent / KOH / diethyl ether; ethanol / 1 h / 20 °C

3: 85 percent / LiBH₄ / tetrahydrofuran / Heating

4: 70 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 20 °C

With potassium hydroxide; lithium borohydride; sodium hypobromide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; 1: Oxidation / 2: Methylation / 3: Reduction / 4: Oxidation;
DOI:10.1021/jo991773c

Reference yield:

: 106454-26-6
(1'R,3'R)-2-(3'-carboxy-2',2'-dimethylcyclobutyl)acetic acid

: 288848-36-2,552810-14-7
(1'R,3'R)-2-(3'-formyl-2',2'-dimethylcyclobutyl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / KOH / diethyl ether; ethanol / 1 h / 20 °C

2: 85 percent / LiBH₄ / tetrahydrofuran / Heating

3: 70 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 20 °C

With potassium hydroxide; lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 1: Methylation / 2: Reduction / 3: Oxidation;
DOI:10.1021/jo991773c