diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Base Information

Chemical Name:diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate
CAS No.:1363334-12-6
Molecular Formula:C₂₁H₂₈NO₅P
Molecular Weight:405.431
Hs Code.:

Synonyms:diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

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Chemical Property of diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

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Technology Process of diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

There total 5 articles about diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1132765-72-0
6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

: 762-04-9
phosphonic acid diethyl ester

: 1363334-12-6
diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: With oxygen; molybdenum(VI) oxide; In methanol; at 60 ℃; for 24h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1363334-12-6
diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

2: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; oxygen; molybdenum(VI) oxide; In methanol; ethylene glycol; isopropyl alcohol;
DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

: 4230-93-7
1,2-dimethoxy-4-(2-nitro-vinyl)-benzene

: 1363334-12-6
diethyl (6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: formic acid / 0.17 h / 0 °C

2.2: 24 h / 50 °C

3.1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

4.1: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; oxygen; molybdenum(VI) oxide; In tetrahydrofuran; methanol; ethylene glycol; isopropyl alcohol;
DOI:10.1016/j.tetlet.2012.01.031