2 3-DICHLORO-N-PHENYLMALEIMIDE

Base Information

• Chemical Name: 2 3-DICHLORO-N-PHENYLMALEIMIDE
• CAS No.: 3876-05-9
• Molecular Formula: C10H5 Cl2 N O2
• Molecular Weight: 242.061
• Hs Code.: 2925190090
• Mol file: 3876-05-9.mol

Synonyms:Maleimide,2,3-dichloro-N-phenyl- (6CI,7CI,8CI);1-Phenyl-3,4-dichloropyrroline-3,4-dione-2,5; 2,3-Dichloro-N-phenylmaleimide;3,4-Dichloro-1-phenyl-1H-pyrrole-2,5-dione; 3,4-Dichloro-1-phenylmaleimide;3,4-Dichloro-N-phenylmaleimide; N-Phenyl-3,4-dichloromaleimide;N-Phenyldichloromaleimide

Chemical Property of 2 3-DICHLORO-N-PHENYLMALEIMIDE

Chemical Property:

• Vapor Pressure: 0.000673mmHg at 25°C
• Melting Point: 198.5-204.5 °C(lit.)
• Refractive Index: 1.654
• Boiling Point: 308.6°C at 760 mmHg
• PKA: -4.86±0.60(Predicted)
• Flash Point: 140.5°C
• PSA: 37.38000
• Density: 1.57g/cm³
• LogP: 2.31400

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dichloro-N-phenylmaleimide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dichloro-N-phenylmaleimide may be used to synthesize:N-phenyl-2,3-di(thiophenyl)maleimideN-phenyl-2,3-dithiomaleimide2-chloro-3-cyclohexyl-N-phenylmaleimide2,3-dicyclohexyl-N-phenylmaleimide2-benzyl-3-chloro-N-phenylmaleimide

Technology Process of 2 3-DICHLORO-N-PHENYLMALEIMIDE

There total 13 articles about 2 3-DICHLORO-N-PHENYLMALEIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

N-phenyl-maleimide (941-69-5) → 3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione (3876-05-9)

Guidance literature:

With thionyl chloride; In pyridine; dichloromethane; for 8h; Heating;

DOI:10.1016/S0040-4020(99)00672-9

Reference yield: 80.0%

dichloromaleic acid anhydride (1122-17-4) + aniline (62-53-3) → 3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione (3876-05-9)

Guidance literature:

In acetic acid; at 85 - 108 ℃; for 2h;

DOI:10.1134/S1070428012030256

Reference yield: 70.3%

→ 3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione (3876-05-9)

Guidance literature:

In acetone; at 20 ℃; for 1h;

With sodium acetate; acetic anhydride; In acetone; Reflux;

upstream raw materials:

N-phenylmaleimide

dichloromaleic acid anhydride

aniline

N-phenyl-maleimide

Downstream raw materials:

2,3-di(1-pyrazolyl)-N-phenylmaleimide

3-Ethoxy-4-imidazol-1-yl-1-phenyl-pyrrole-2,5-dione

3,4-Di-imidazol-1-yl-1-phenyl-pyrrole-2,5-dione

10-Methyl-2-phenyl-1H-2,3,9,10-tetrahydropyrrolo<3,4-b><1,4>benzoxazepine-1,3,9-trione

Refernces

• 1、 Xu, Wen-Lei,Tang, Lei,Ge, Chen-Yu,Chen, Jie,Zhou, Ling. "Synthesis of Tetrahydroisoindolinones via a Metal-Free Dehydrogenative Diels-Alder Reaction". supporting information. p. 2268 - 2273. Retrieved 2019/04/10.
• 2、 Fan, Yongxian,Lu, Yuele,Chen, Xiaolong,Tekwani, Babu,Li, Xing-Cong,Shen, Yinchu. "Anti-leishmanial and cytotoxic activities of a series of maleimides: Synthesis, biological evaluation and structure-activity relationship". . . Retrieved 2018/11/24.