bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Base Information

Chemical Name:bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate
CAS No.:1345025-43-5
Molecular Formula:C₁₆H₁₉F₆O₈P
Molecular Weight:484.286
Hs Code.:

Synonyms:bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

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Chemical Property of bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

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Technology Process of bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

There total 2 articles about bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 757-95-9
bis(2,2,2-trifluoroethyl)(methyl)phosphonate

: 2,4-bis-methoxymethoxy-benzoic acid methoxymethyl ester

: 1345025-43-5
bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -50 ℃; for 0.0333333h; Inert atmosphere;
DOI:10.1248/cpb.59.885

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1345025-43-5
bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.03 h / -50 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1248/cpb.59.885

Reference yield: 98.0%

: 1345025-43-5
bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate

: 5339-06-0
4-formylphenyl benzoate

: 1345025-47-9
C₂₆H₂₄O₇

: 1345025-23-1
C₂₆H₂₄O₇

Guidance literature:: bis(2,2,2-trifluoroethyl) 2-[2,4-bis(methoxymethoxy)phenyl]-2-oxoethylphosphonate; With 18-crown-6 ether; potassium carbonate; In toluene; acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

4-formylphenyl benzoate; In toluene; acetonitrile; at -20 ℃; for 5h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1248/cpb.59.885