(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

Base Information

Chemical Name:(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate
CAS No.:1610776-29-8
Molecular Formula:C₄₀H₄₉NO₅Si
Molecular Weight:651.918
Hs Code.:

Synonyms:(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

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Technology Process of (E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

There total 9 articles about (E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2936-08-5
valproyl chloride

: 1610776-23-2
(E)-5-((tert-butyldiphenylsilyloxy)methyl)-5-(hydroxymethyl)-3-((1-methyl-1H-indol-4-yl)methylene)dihydrofuran-2(3H)-one

: 1610776-29-8
(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2014.04.024

Reference yield:

: C₃₈H₅₁NO₅Si₂

: 1610776-29-8
(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

3: pyridinium p-toluenesulfonate / ethanol / 60 °C

4: dmap; triethylamine / dichloromethane / 20 °C

With dmap; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2014.04.024

Reference yield:

: C₃₉H₅₃NO₇SSi₂

: 1610776-29-8
(E)-(2-((tert-butyldiphenylsilyloxy)methyl)-4-((1-methyl-1H-indol-4-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

2: pyridinium p-toluenesulfonate / ethanol / 60 °C

3: dmap; triethylamine / dichloromethane / 20 °C

With dmap; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2014.04.024