1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

Base Information

Chemical Name:1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide
CAS No.:871714-91-9
Molecular Formula:C₂₀H₁₉N₃O₃S
Molecular Weight:381.455
Hs Code.:

Synonyms:1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

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Chemical Property of 1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

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Technology Process of 1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

There total 11 articles about 1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 733739-70-3
1-{2-[4-(Benzyloxy)phenyl]ethyl}-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

: 871714-91-9
1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; atmospheric pressure;
DOI:10.1021/jm0503897

Reference yield:

: 170874-51-8
5,11-dihydro-5-methylbenzo[f]pyrido[3,2-c][1,2,5]thiadiazepine 6,6-dioxide

: 871714-91-9
1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 3 h / 60 °C

1.2: 60 percent / dimethylformamide / 24 h / 60 °C

2.1: 60 percent / H₂ / Pd/C / methanol / 20 °C / atmospheric pressure

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0503897

Reference yield:

: 170874-56-3
2-amino-N-(2-chloro-pyridin-3-yl)-N-methyl-benzenesulfonamide

: 871714-91-9
1-[2-(4-phenol)ethyl]-5-methyl-1,5-dihydropyrido[3,2-c][1,2,5]benzothiadiazepine 6,6-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 12 h / 20 °C

2.1: 67 percent / K₂CO₃; Cu / dimethylformamide / 8 h / Heating

3.1: NaH / dimethylformamide / 3 h / 60 °C

3.2: 60 percent / dimethylformamide / 24 h / 60 °C

4.1: 60 percent / H₂ / Pd/C / methanol / 20 °C / atmospheric pressure

With hydrogen; copper; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0503897