(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Base Information

Chemical Name:(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid
CAS No.:145827-51-6
Molecular Formula:C₁₃H₁₅N₃O₆S
Molecular Weight:341.345
Hs Code.:

(1S,5R)-2-<D-2-(4-hydroxyphenyl)glycyl>-7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Synonyms:(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Suppliers and Price of (1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

There total 10 articles about (1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: tert-butyl <(R)-4-hydroxy-α-<<(1S,5R)-7-oxo-6-sulfo-2,6-diazabicyclo<3.2.0>hept-2-yl>carbonyl>benzyl>carbamate triethylammonium salt

: 145827-51-6
(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Guidance literature:: With trifluoroacetic acid; at -10 ℃; for 1h;
DOI:10.1021/jm980023c

Reference yield:

: 145574-16-9
benzyl (1S,5R)-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate

: 145827-51-6
(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / H₂ / Pd/C / methanol

2: 77 percent / DMAP / tetrahydrofuran / 3 h / Ambient temperature

3: 1.) DMF*SO₃, 2.) H₂O / 1.) below 5 deg C, 3 h, 2.) overnight

4: 30 percent / dimethylformamide / 4 h

5: 60 percent / TFA / 1 h / -10 °C

With dmap; sulfur trioxide-N,N-dimethylformamide complex; water; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980023c

Reference yield:

: 145574-13-6
benzyl (1S,4S,5S)-6-(3,4-dimethoxybenzyl)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate

: 145827-51-6
(1S,5R)-2--7-oxo-2,6-diazabicyclo<3.2.0>heptane-6-sulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / CH₂Cl₂ / 2 h / below 10 deg C

2: NaBH₄ / tetrahydrofuran; dimethylformamide / 0 °C

3: 68 percent / K₂S₂O₈, NaHCO₃ / acetonitrile; H₂O / 100 °C / pH 4.5

4: 72 percent / H₂ / Pd/C / methanol

5: 77 percent / DMAP / tetrahydrofuran / 3 h / Ambient temperature

6: 1.) DMF*SO₃, 2.) H₂O / 1.) below 5 deg C, 3 h, 2.) overnight

7: 30 percent / dimethylformamide / 4 h

8: 60 percent / TFA / 1 h / -10 °C

With pyridine; dmap; sodium tetrahydroborate; dipotassium peroxodisulfate; sulfur trioxide-N,N-dimethylformamide complex; water; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980023c