N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate

Base Information

• Chemical Name: N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate
• CAS No.: 80228-10-0
• Molecular Formula: C₂₇H₂₆ClN₆O₈P
• Molecular Weight: 628.966

Synonyms:N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate

Chemical Property of N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate

Chemical Property:

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Technology Process of N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate

There total 1 articles about N-benzoyl-O⁶-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphoric acid (2R,3S,5R)-5-(2-benzoylamino-6-methoxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester (80228-09-7) → N-benzoyl-O6-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate (80228-10-0)

Guidance literature:

With benzene-sulfonic acid monohydrate; In methanol; chloroform; for 0.0833333h; Yield given; Ambient temperature;

DOI:10.1021/ja00368a023

Reference yield:

5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorphenylcyanoethyl phosphate) (67221-57-2) + N-benzoyl-O6-methyldeoxyguanosine 3'-p-chlorophenyl cyanoethyl phosphate (80228-10-0) → dDMTrTp(O6-Me)GBzpCE (80228-11-1)

Guidance literature:

With pyridine; water; triethylamine; Yield given. Multistep reaction; 1.) pyridine, 0.5 h, 2.) 3 h;

DOI:10.1021/ja00368a023

upstream raw materials:

Phosphoric acid (2R,3S,5R)-5-(2-benzoylamino-6-methoxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester

Downstream raw materials:

dDMTrTp(O⁶-Me)G^BzpCE

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