Technology Process of 2-((benzyloxy)methoxy)-1-bromo-4-methoxybenzene
There total 1 articles about 2-((benzyloxy)methoxy)-1-bromo-4-methoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -20 - 20 ℃;
Inert atmosphere;
DOI:10.1002/anie.201006367
- Guidance literature:
-
2-((benzyloxy)methoxy)-1-bromo-4-methoxybenzene;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
With
Trimethyl borate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
With
water; ammonium chloride;
In
tetrahydrofuran;
Saturated solution;
DOI:10.1002/anie.201006367
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C / Inert atmosphere
1.3: Saturated solution
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 2.5 h / 70 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 25 °C
4.1: pyridine / dichloromethane / 12 h / 25 °C / Inert atmosphere
5.1: water; acetic acid / 60 h / 20 °C / Inert atmosphere
6.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
7.1: 20% palladium(II) hydroxide on carbon; hydrogen / ethyl acetate / 0.33 h / 20 °C
With
pyridine; 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium(0); 20% palladium(II) hydroxide on carbon; palladium 10% on activated carbon; water; hydrogen; tert.-butyl lithium; sodium carbonate; acetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
2.1: Suzuki-Miyaura reaction;
DOI:10.1002/anie.201006367
