(2R,5S)-2,5-diisopropylcyclohexanone

Base Information

• Chemical Name: (2R,5S)-2,5-diisopropylcyclohexanone
• CAS No.: 1214747-73-5
• Molecular Formula: C₁₂H₂₂O
• Molecular Weight: 182.306
• Mol file: 1214747-73-5.mol

Synonyms:(2R,5S)-2,5-diisopropylcyclohexanone

Chemical Property of (2R,5S)-2,5-diisopropylcyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-2,5-diisopropylcyclohexanone

There total 3 articles about (2R,5S)-2,5-diisopropylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2R,5S)-2-isopropyl-5-(propen-2-yl)-cyclohexanone (1214747-79-1) → (2R,5S)-2,5-diisopropylcyclohexanone (1214747-73-5)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; for 1h;

DOI:10.1016/j.ejmech.2009.10.039

Reference yield:

trans-1,4-diisopropylcyclohexane (4789-29-1) → (2R,5S)-2,5-diisopropylcyclohexanone (1214747-73-5) + (2S,5R)-2,5-diisopropylcyclohexanone

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 50 ℃; for 168h; Overall yield = 87 %; Overall yield = 94 mg; enantioselective reaction;

DOI:10.1021/jacs.6b12113

Reference yield:

1,4-diisopropyl-1,4-cyclohexadiene (114300-89-9) → (2R,5S)-2,5-diisopropylcyclohexanone (1214747-73-5) + (2S,5R)-2,5-diisopropylcyclohexanone

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 1551.49 Torr

2: dihydrogen peroxide / acetonitrile / 168 h / 50 °C

With palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; In ethyl acetate; acetonitrile;

DOI:10.1021/jacs.6b12113

upstream raw materials:

(2R,5S)-2-isopropyl-5-(propen-2-yl)-cyclohexanone

1,4-diisopropyl-1,4-cyclohexadiene

trans-1,4-diisopropylcyclohexane