3,4-dimethyl-5-phenylpyridine

Base Information

• Chemical Name: 3,4-dimethyl-5-phenylpyridine
• CAS No.: 27063-82-7
• Molecular Formula: C₁₃H₁₃N
• Molecular Weight: 183.253
• Mol file: 27063-82-7.mol

Synonyms:3,4-dimethyl-5-phenylpyridine

Chemical Property of 3,4-dimethyl-5-phenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dimethyl-5-phenylpyridine

There total 3 articles about 3,4-dimethyl-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethyl-1H-pyrrole (822-51-5) + 3-chloro-3-phenyl-3H-diazirine (4460-46-2) → 4,5-dimethyl-2-phenylpyridine (27063-84-9) + 3,4-dimethyl-5-phenylpyridine (27063-82-7)

Guidance literature:

With sodium carbonate; In acetonitrile; at 59 ℃; for 12h; Overall yield = 58 percent; Sealed tube;

DOI:10.1021/jacs.1c06287

Reference yield:

benzamidine monohydrochloride (1670-14-0) → 4,5-dimethyl-2-phenylpyridine (27063-84-9) + 3,4-dimethyl-5-phenylpyridine (27063-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium chloride; sodium chloride; sodium hypochlorite / dimethyl sulfoxide; pentane / 0 °C

2: sodium carbonate / acetonitrile / 12 h / 59 °C / Sealed tube

With sodium hypochlorite; sodium carbonate; lithium chloride; sodium chloride; In dimethyl sulfoxide; acetonitrile; pentane; 2: |Ciamician-Dennstedt Rearrangement;

DOI:10.1021/jacs.1c06287

Reference yield:

→ 3,4-dimethyl-5-phenylpyridine (27063-82-7)

Guidance literature:

3,4-Dimethylpyridin, Benzoylperoxid;

upstream raw materials:

3,4-dimethyl-1H-pyrrole

3-chloro-3-phenyl-3H-diazirine

benzamidine monohydrochloride

Refernces