(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one
CAS No.:1333501-71-5
Molecular Formula:C₁₅H₂₁N₃O₃
Molecular Weight:291.35
Hs Code.:

Synonyms:(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

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Technology Process of (4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

There total 4 articles about (4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1333501-69-1
(4S,5R)-4-(4-phenylpiperazin-1-ylmethyl)-5-trityloxymethyloxazolidinoxazolidin-2-one

: 1333501-71-5
(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 0.166667h;
DOI:10.1021/jm2006904

Reference yield:

: C₃₀H₂₅NO₆

: 1333501-71-5
(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / water; acetone / 72 h / 20 °C

2: dichloromethane / 14 h / -79 - 109 °C

3: dichloromethane / 2 h / 20 °C

4: hydrogenchloride / water; ethyl acetate / 0.17 h / 20 °C

With hydrogenchloride; sodium azide; In dichloromethane; water; ethyl acetate; acetone;
DOI:10.1021/jm2006904

Reference yield:

: 1333501-61-3
(R)-1-(triphenylmethoxy)-2-[(azidocarbonyl)oxy]-3-butene

: 1333501-71-5
(4S,5R)-5-hydroxymethyl-4-(4-phenylpiperazin-1-ylmethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 14 h / -79 - 109 °C

2: dichloromethane / 2 h / 20 °C

3: hydrogenchloride / water; ethyl acetate / 0.17 h / 20 °C

With hydrogenchloride; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2006904