[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

Base Information

Chemical Name:[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol
CAS No.:929198-08-3
Molecular Formula:C₂₅H₂₁NO₆S
Molecular Weight:463.511
Hs Code.:

[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2<i>H</i>-3-oxa-6-aza-<i>as</i>-indacen-1-yl]-methanol

Synonyms:[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

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Chemical Property of [2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

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Technology Process of [2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

There total 10 articles about [2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 929198-09-4
3-benzo[1,3]dioxol-5-yl-2-[5-(2,2-dimethyl-propionyloxy)-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-3-hydroxy-propionic acid methyl ester

: 929198-08-3
[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200600922

Reference yield:

: 850888-88-9
N-(4-hydroxy-5,8-dihydro-naphthalen-1-yl)-4-methyl-benzenesulfonamide

: 929198-08-3
[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / Et₃N / tetrahydrofuran / 24 h / 20 °C

2.1: osmium tetroxide; N-methylmorpholine-N-oxide / tetrahydrofuran; H₂O / 72 h

2.2: NaIO₄ / tetrahydrofuran; H₂O / 4 h

2.3: 80 percent / conc. sulfuric acid / tetrahydrofuran

3.1: NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 3.5 h / 20 °C

4.1: 3.22 g / methanol; benzene / 20 °C

5.1: 76 percent / dicyclohexyliodoborane; Et₃N / CCl₄ / 24 h / 20 °C

6.1: 70 percent / DIBAL / tetrahydrofuran / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; B-iododicyclohexylborane; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1002/ejoc.200600922

Reference yield:

: 929198-12-9
2,2-dimethyl-propionic acid 4-(2-oxo-ethyl)-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

: 929198-08-3
[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 3.5 h / 20 °C

2: 3.22 g / methanol; benzene / 20 °C

3: 76 percent / dicyclohexyliodoborane; Et₃N / CCl₄ / 24 h / 20 °C

4: 70 percent / DIBAL / tetrahydrofuran / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; B-iododicyclohexylborane; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; tert-butyl alcohol; benzene;
DOI:10.1002/ejoc.200600922