(S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane

Base Information

• Chemical Name: (S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane
• CAS No.: 1272031-58-9
• Molecular Formula: C₁₉H₂₈BFO₂
• Molecular Weight: 318.24
• Mol file: 1272031-58-9.mol

Synonyms:(S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane

Chemical Property of (S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane

There total 1 articles about (S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-cyclohexyl-5,5-dimethyl-1,3,2-dioxaborinane (879224-90-5) + (S)-(-)-1-(2-fluorophenyl)ethyl N,N-diisopropylcarbamate (1240815-56-8) → (S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane (1272031-58-9)

Guidance literature:

(S)-(-)-1-(2-fluorophenyl)ethyl N,N-diisopropylcarbamate; With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 0.5h; Inert atmosphere;

2-cyclohexyl-5,5-dimethyl-1,3,2-dioxaborinane; In diethyl ether; hexane; cyclohexane; at -78 - 25 ℃; for 17.25h; Inert atmosphere;

DOI:10.1002/anie.201006037

Reference yield:

(S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane (1272031-58-9) → potassium (S)-(1,4-diphenylhexen-4-yl)trifluoroborate

Guidance literature:

With potassium hydrogenfluoride; In methanol; water; at 20 ℃; for 0.5h; Saturated solution;

DOI:10.1002/anie.201006037

Reference yield:

(S)-2-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]-5,5-dimethyl-1,3,2-dioxaborinane (1272031-58-9) → (R)-N-benzyl-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]amine (1272031-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydrogenfluoride / methanol; water / 0.5 h / 20 °C / Saturated solution

2.1: tetrachlorosilane / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 80 °C / Inert atmosphere

2.3: 1 h

With tetrachlorosilane; potassium hydrogenfluoride; In methanol; water; 1,2-dichloro-ethane;

DOI:10.1002/anie.201006037

upstream raw materials:

2-cyclohexyl-5,5-dimethyl-1,3,2-dioxaborinane

(S)-(-)-1-(2-fluorophenyl)ethyl N,N-diisopropylcarbamate

Downstream raw materials:

(R)-N-benzyl-[1-cyclohexyl-1-(2-fluorophenyl)ethyl]amine