rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

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Chemical Name:rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide
CAS No.:1236303-60-8
Molecular Formula:C₂₃H₂₇F₃N₂O₂S
Molecular Weight:452.541
Hs Code.:

Synonyms:rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

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Chemical Property of rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

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Technology Process of rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

There total 6 articles about rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1208984-79-5
2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid

: 1236302-36-5
rac-1-methyl-3-p-tolyl-piperidin-3-ylamine

: 1236303-60-8
rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/ml500005m

Reference yield:

: 61995-20-8
N-(benzyloxycarbonyl)-3-piperidone

: 1236303-60-8
rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.75 h / 20 °C

2: sodium azide / water; trifluoroacetic acid / 3 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C

With lithium aluminium tetrahydride; sodium azide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/ml500005m

Reference yield:

: 1558681-40-5
C₂₀H₂₂N₄O₂

: 1236303-60-8
rac-2-methoxy-6-methylsulfanyl-N-(1-methyl-3-p-tolyl-piperidin-3-yl)-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ml500005m