2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Base Information

• Chemical Name: 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline
• CAS No.: 102729-49-7
• Molecular Formula: C₁₅H₁₃F₃N₂
• Molecular Weight: 278.277
• Mol file: 102729-49-7.mol

Synonyms:2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Chemical Property of 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline

There total 10 articles about 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

→ 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline (102729-49-7)

Guidance literature:

With tetrahydroxydiboron; copper diacetate; In acetonitrile; at 80 ℃; for 12h; Schlenk technique;

Reference yield: 77.0%

3-chloro-2-phenyl-6-trifluoromethylquinoxaline (102729-48-6) → 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline (102729-49-7)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; at 18 ℃; for 1h; under 2280 Torr;

Reference yield:

2-chloro-3-nitro-5-trifluoromethylbenzene (121-17-5) → 2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline (102729-49-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent Turnov_. / NaHCO₃ / ethanol; H₂O / 24 h / Heating

2: 57 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 18 °C / 740 Torr

3: 70 percent / 10percent NaOH, 30percent H₂O₂ / 1 h / 100 °C

4: 84 percent / POCl₃ / 2 h / Heating

5: 77 percent / H₂, NEt₃ / 10percent Pd/C / ethanol / 1 h / 18 °C / 2280 Torr

With sodium hydroxide; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; water;

upstream raw materials:

3-chloro-2-phenyl-6-trifluoromethylquinoxaline

2-chloro-3-nitro-5-trifluoromethylbenzene

Benzoylformic acid

phenylglycin

Downstream raw materials:

3,4-dihydro-3-methyl-2-phenyl-6-trifluoromethylquinoxaline

2-methyl-3-phenyl-7-trifluoromethylquinoxaline 1-oxide

3-phenyl-7-trifluoromethylquinoxaline N-oxide

3-methyl-2-phenyl-6-trifluoromethylquinoxaline