Technology Process of N-{4-methyl-3-[2-(pyrimidin-5-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenyl}-3-trifluoromethyl benzamide
There total 8 articles about N-{4-methyl-3-[2-(pyrimidin-5-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenyl}-3-trifluoromethyl benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux
2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C
3: 12 h / Reflux
4: sodium acetate / ethanol / 12 h / Reflux
5: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / Inert atmosphere; Reflux
6: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 12 h / 20 °C
7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C
With
sulfuric acid; water; hydrogen; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux
2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C
3: 12 h / Reflux
4: sodium acetate / ethanol / 12 h / Reflux
5: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / Inert atmosphere; Reflux
6: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 12 h / 20 °C
7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C
With
sulfuric acid; water; hydrogen; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;
