diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

Base Information

Chemical Name:diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate
CAS No.:159117-09-6
Molecular Formula:C₁₈H₃₂NO₄P
Molecular Weight:357.43
Hs Code.:

Synonyms:diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

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Chemical Property of diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

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Technology Process of diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

There total 7 articles about diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 72726-66-0
diethyl phosphite lithium salt

: 159171-44-5
((R)-2-Methoxy-1-phenyl-ethyl)-[3-methyl-but-(E)-ylidene]-amine

: 159117-09-6
diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

Guidance literature:: In tetrahydrofuran; for 20h; Ambient temperature;
DOI:10.1021/ja00099a084

Reference yield:

: 64715-85-1,91298-74-7,127180-88-5
(R)-2-methoxy-1-phenylethylamine

: 159117-09-6
diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Na₂SO₄ / benzene / 1.5 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, RT, 18 h

With n-butyllithium; sodium sulfate; In benzene;
DOI:10.1021/ja00149a011

Reference yield:

: 875-74-1
(R)-phenylglycine

: 159117-09-6
diethyl (R)-(-)-[1-((N-(R)-(1-phenyl-2-methoxyethyl)amino)-3-methylbutyl)]phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KH / 1.) THF, overnight, 2.) THF, 3 h

2: 82 percent / Na₂SO₄ / benzene / 1.5 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, RT, 18 h

With n-butyllithium; potassium hydride; sodium sulfate; In benzene;
DOI:10.1021/ja00149a011