(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

Base Information

Chemical Name:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide
CAS No.:1286280-37-2
Molecular Formula:C₂₇H₃₉N₃O₂S
Molecular Weight:469.692
Hs Code.:

Synonyms:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

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Chemical Property of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

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Technology Process of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

There total 9 articles about (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1286280-53-2
(1S,2S)-2-thiophen-2yl-cyclopropanecarboxylic chloride

: C₁₉H₃₃N₃O*(x)ClH

: 1286280-37-2
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 1286280-37-2
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: borane-THF / tetrahydrofuran / 0 - 50 °C

4.2: 0.17 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 55 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

8.1: triethylamine / dichloromethane / 1.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; borane-THF; tetrabutyl ammonium fluoride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 27460-85-1
N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine

: 1286280-37-2
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid [(R)-1-[4-(2-methyl-pentyloxy)phenyl]-2-(4-methyl-piperazin-1-yl)ethyl]amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: borane-THF / tetrahydrofuran / 0 - 50 °C

3.2: 0.17 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 55 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

7.1: triethylamine / dichloromethane / 1.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; borane-THF; tetrabutyl ammonium fluoride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;