Technology Process of 3-benzoyl-3-hydroxy-2-phenylisoindolin-1-one
There total 6 articles about 3-benzoyl-3-hydroxy-2-phenylisoindolin-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-iodo-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide;
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;
In
isopropyl alcohol;
at 20 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
With
triethylamine;
In
isopropyl alcohol;
at 70 ℃;
Schlenk technique;
Inert atmosphere;
With
oxygen;
In
isopropyl alcohol;
for 24h;
Schlenk technique;
Inert atmosphere;
DOI:10.1055/s-0033-1339449
- Guidance literature:
-
With
potassium peroxomonosulphate; tetrabutylammomium bromide;
In
1,4-dioxane; water;
at 80 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / 55 °C / Inert atmosphere
2: methanol; sodium hydroxide / 2 h / 20 °C
3: thionyl chloride / 2 h / 90 °C
4: potassium carbonate / ethyl acetate; water / 1.17 h / 0 - 20 °C
5: tetrabutylammomium bromide; potassium peroxomonosulphate / water; 1,4-dioxane / 10 h / 80 °C
With
methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; potassium peroxomonosulphate; tetrabutylammomium bromide; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;
