2-(BROMOMETHYL)-5-NITROBENZONITRILE

Base Information

• Chemical Name: 2-(BROMOMETHYL)-5-NITROBENZONITRILE
• CAS No.: 288252-67-5
• Molecular Formula: C8H5 Br N2 O2
• Molecular Weight: 241.044
• Hs Code.: 2926909090
• Mol file: 288252-67-5.mol

Synonyms:2-(BROMOMETHYL)-5-NITROBENZONITRILE

Chemical Property of 2-(BROMOMETHYL)-5-NITROBENZONITRILE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 130 °C
• Refractive Index: 1.619
• Boiling Point: 344.857°C at 760 mmHg
• Flash Point: 162.364°C
• PSA: 69.61000
• Density: 1.701g/cm³
• LogP: 2.88458
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromomethyl-5-nitro-benzonitrile 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BROMOMETHYL)-5-NITROBENZONITRILE

There total 2 articles about 2-(BROMOMETHYL)-5-NITROBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-(bromomethyl)benzonitrile (22115-41-9) → 2-(bromomethyl)-5-nitrobenzonitrile (288252-67-5)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃; for 18h;

DOI:10.1246/cl.2006.620

Reference yield:

2-cyano-4-nitrotoluene (939-83-3) → 2-(bromomethyl)-5-nitrobenzonitrile (288252-67-5)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Heating;

DOI:10.1021/ol050331m

Reference yield: 100.0%

1-(1-methyl-1H-imidazol-2-yl)-2-phenylethan-1-one + 2-(bromomethyl)-5-nitrobenzonitrile (288252-67-5) → C20H16N4O3

Guidance literature:

With disodium hydrogenphosphate; C₃₈H₃₈IrN₄S₂⁽¹⁺⁾*F₆P^(1-); In tetrahydrofuran; methanol; at 40 ℃; for 1.5h; Reagent/catalyst; Solvent; Temperature; enantioselective reaction; Mechanism; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1038/nature13892

upstream raw materials:

2-cyano-4-nitrotoluene

2-(bromomethyl)benzonitrile

Downstream raw materials:

diethyl (2-cyano-4-nitrobenzyl)acetamidomalonate

diethyl (4-amino-2-cyanobenzyl)acetamidomalonate

2-(4-morpholinopiperidin-1-ylmomethyl)-5-nitrobenzonitrile

(R)-2-(2-formyloctyl)-5-nitrobenzonitrile

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