5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Base Information

Chemical Name:5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride
CAS No.:603123-68-8
Molecular Formula:C₂₆H₂₆ClNO₅*ClH
Molecular Weight:504.41
Hs Code.:

Synonyms:5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Suppliers and Price of 5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

There total 13 articles about 5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2788-86-5,53649-47-1,97466-49-4,21019-51-2
(R)-2-(4-chlorophenyl)oxirane

: 603123-68-8
5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 18 h / Reflux

2: tetrahydrofuran / 12 h / 20 °C

3: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

4: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 20 °C / pH 4 / aq. phosphate buffer

5: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; sodium chlorite; dihydrogen peroxide; copper diacetate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm800222k

Reference yield:

: 603123-54-2
C₃₁H₃₄ClNO₇

: 603123-68-8
5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 603123-68-8
5-[((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methoxybenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: AD-mixβ; water / tert-butyl alcohol / 4 h / Cooling with ice

2: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / Cooling with ice

3: ethanol / 18 h / Reflux

4: tetrahydrofuran / 12 h / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: sodium chlorite; dihydrogen peroxide / water; acetonitrile / 20 °C / pH 4 / aq. phosphate buffer

7: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; Trimethyl orthoacetate; sodium chlorite; chloro-trimethyl-silane; AD-mixβ; water; dihydrogen peroxide; copper diacetate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm800222k