ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

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Chemical Name:ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate
CAS No.:862814-75-3
Molecular Formula:C₂₈H₃₄N₄O₉S₂
Molecular Weight:634.731
Hs Code.:

Synonyms:ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

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Chemical Property of ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

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Technology Process of ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

There total 4 articles about ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 380897-71-2
(3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide

: 862785-89-5
ethyl α-[6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

: 862814-75-3
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

Guidance literature:: With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1080/15257770701296952

Reference yield:

: 5334-32-7
1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione

: 862814-75-3
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / aq. sodium hydroxide / 3 h / 20 °C

2: 75 percent / 18-crown-6; potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C

With sodium hydroxide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1080/15257770701296952

Reference yield:

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 862814-75-3
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-(1'-carboethoxyethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thiopropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / aq. sodium hydroxide / 3 h / 20 °C

2: 75 percent / 18-crown-6; potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C

With sodium hydroxide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1080/15257770701296952