Technology Process of (2R,5S)-9-bromo-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-dien-6-one
There total 3 articles about (2R,5S)-9-bromo-2-phenyl-1,4-dioxaspiro[4.5]deca-7,9-dien-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 28 percent / potassium carbonate; potassium iodide / toluene / 120 h / 150 °C
2: 34 percent / KOH / 0 °C / Electrolysis
3: 53 percent / TFA; water / diethyl ether / 1 h / 0 °C
With
potassium hydroxide; water; potassium carbonate; trifluoroacetic acid; potassium iodide;
In
diethyl ether; toluene;
1: Williamson etherification;
DOI:10.1021/ol048030k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: peracetic acid; acetic acid / ethyl acetate / cooling
1.2: 65 percent / KOH / methanol / 0.5 h / 0 °C
2.1: 28 percent / potassium carbonate; potassium iodide / toluene / 120 h / 150 °C
3.1: 34 percent / KOH / 0 °C / Electrolysis
4.1: 53 percent / TFA; water / diethyl ether / 1 h / 0 °C
With
peracetic acid; potassium hydroxide; water; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide;
In
diethyl ether; ethyl acetate; toluene;
2.1: Williamson etherification;
DOI:10.1021/ol048030k
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 34 percent / KOH / 0 °C / Electrolysis
2: 53 percent / TFA; water / diethyl ether / 1 h / 0 °C
With
potassium hydroxide; water; trifluoroacetic acid;
In
diethyl ether;
DOI:10.1021/ol048030k
