dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

Base Information

Chemical Name:dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate
CAS No.:1227268-38-3
Molecular Formula:C₅₀H₅₁BrFNO₇Si
Molecular Weight:904.945
Hs Code.:

dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

Synonyms:dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

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Chemical Property of dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

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Technology Process of dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

There total 1 articles about dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227268-34-9
(3R,4S)-4-[2-(allyloxy)-4-iodophenyl]-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]azetidin-2-one

: 479400-43-6
2-prop-2-ynylmalonic acid dibenzyl ester

: 1227268-38-3
dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

: 1227268-39-4
dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-(4-{5-(benzyloxy)-4-[(benzyloxy)carbonyl]-5-oxopent-1-yn-1-yl}phenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

Guidance literature:: With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

: 933045-04-6
1-but-3-yn-1-yl-1H-1,2,4-triazole

: 1227268-38-3
dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

: 1227268-41-8
dibenzyl {3-[4-((2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-{4-[4-(1H-1,2,4-triazol-1-yl)but-1-yn-1-yl]phenyl}azetidin-2-yl)-3-hydroxyphenyl]prop-2-yn-1-yl}malonate

Guidance literature:: 1-but-3-yn-1-yl-1H-1,2,4-triazole; dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate; With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 70 ℃; for 7h; Inert atmosphere; Sealed tube;

With water; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 933045-04-6
1-but-3-yn-1-yl-1H-1,2,4-triazole

: 1227268-38-3
dibenzyl [3-(4-{(2S,3R)-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}-3-hydroxyphenyl)prop-2-yn-1-yl]malonate

: 1227268-41-8
dibenzyl {3-[4-((2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-{4-[4-(1H-1,2,4-triazol-1-yl)but-1-yn-1-yl]phenyl}azetidin-2-yl)-3-hydroxyphenyl]prop-2-yn-1-yl}malonate

: 1227268-40-7
dibenzyl {3-[4-((2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-{4-[4-(1H-1,2,4-triazol-1-yl)but-1-yn-1-yl]phenyl}azetidin-2-yl)-3-hydroxyphenyl]prop-2-yn-1-yl}malonate

Guidance literature:: With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 70 ℃; for 7h; Inert atmosphere; Sealed tube;