methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

Base Information

Chemical Name:methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate
CAS No.:1266683-66-2
Molecular Formula:C₂₉H₃₈N₄O₆
Molecular Weight:538.644
Hs Code.:

Synonyms:methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

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Chemical Property of methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

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Technology Process of methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

There total 14 articles about methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

: 1266683-65-1
methyl 3-azido-5-isobutoxybenzoate

: 1266683-62-8
N-Boc-3-ethynyl-5-isobutoxyaniline

: 1266683-66-2
methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 32 ℃; Inert atmosphere; Darkness;
DOI:10.1002/chem.201001560

Reference yield:

: 1266683-61-7
N-Boc-3-(3-hydroxy-3-methylbut-1-ynyl)-5-isobutoxyaniline

: 1266683-66-2
methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / toluene / 1 h / Reflux

2: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 32 °C / Inert atmosphere; Darkness

With sodium hydride; copper(II) sulfate; sodium L-ascorbate; In water; toluene; tert-butyl alcohol;
DOI:10.1002/chem.201001560

Reference yield:

: 1266683-59-3
N-Boc-3-bromo-5-isobutoxyaniline

: 1266683-66-2
methyl 3-(4-(3-(N-Boc-amino)-5-isobutoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-isobutoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / 48 h / 78 °C / Inert atmosphere

2: sodium hydride / toluene / 1 h / Reflux

3: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 32 °C / Inert atmosphere; Darkness

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; copper(II) sulfate; sodium L-ascorbate; diisopropylamine; In water; toluene; tert-butyl alcohol; 1: Sonogashira coupling;
DOI:10.1002/chem.201001560