(R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

Base Information

Chemical Name:(R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
CAS No.:1331961-03-5
Molecular Formula:C₂₅H₂₉ClN₂O₉
Molecular Weight:536.966
Hs Code.:

Synonyms:(R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

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Chemical Property of (R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

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Technology Process of (R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

There total 2 articles about (R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

: 1155873-40-7
C₁₅H₁₇NO₇

: 14173-40-1,23434-91-5,33965-47-8,60594-65-2
(S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride

: 1331961-03-5
(R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/ardp.201100109

Reference yield:

: 14173-39-8,1991-78-2
p-chlorophenylalanine

: 1331961-03-5
(R)-5-((S)-3-(4-chlorophenyl)-1-methoxy-1-oxopropan-2-ylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 0 °C

2: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane;
DOI:10.1002/ardp.201100109