5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

Base Information

Chemical Name:5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine
CAS No.:1007208-67-4
Molecular Formula:C₂₀H₂₁N₇O
Molecular Weight:375.433
Hs Code.:

Synonyms:5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

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Chemical Property of 5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

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Technology Process of 5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

There total 12 articles about 5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-7-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine

: 1007208-67-4
5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

Guidance literature:: With N-acetylcystein; trifluoroacetic acid; at 70 ℃; for 3h;
DOI:10.1016/j.bmc.2015.11.009

Reference yield:

: 1007206-27-0
4-[4,6-dichloro-5-(2-chloroethyl)-pyrimidin-2-yl]-morpholine

: 1007208-67-4
5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / Reflux

2: caesium carbonate; sodium iodide / acetonitrile / 24 h / Reflux

3: sulfuric acid; trifluoroacetic acid / 5 h / Reflux

4: pyridine; dmap / acetonitrile / 0.25 h / 0 - 20 °C

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere; Irradiation

6: water; sodium hydroxide / tetrahydrofuran / 10 h / Reflux

7: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 8 h / 100 °C / Inert atmosphere; Irradiation

8: N-acetylcystein; trifluoroacetic acid / 3 h / 70 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; potassium phosphate; N-acetylcystein; sulfuric acid; water; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 5: |Suzuki-Miyaura Coupling / 7: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2015.11.009

Reference yield:

: 127915-15-5,19406-00-9
2-oxotetrahydrofuran-3-carboxylic acid methyl ester

: 1007208-67-4
5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1: sodium / methanol / 2 h / Reflux

2: trichlorophosphate / 10 h / 100 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / Reflux

4: caesium carbonate; sodium iodide / acetonitrile / 24 h / Reflux

5: sulfuric acid; trifluoroacetic acid / 5 h / Reflux

6: pyridine; dmap / acetonitrile / 0.25 h / 0 - 20 °C

7: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere; Irradiation

8: water; sodium hydroxide / tetrahydrofuran / 10 h / Reflux

9: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / N,N-dimethyl-formamide / 8 h / 100 °C / Inert atmosphere; Irradiation

10: N-acetylcystein; trifluoroacetic acid / 3 h / 70 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; dmap; potassium phosphate; N-acetylcystein; sulfuric acid; water; palladium diacetate; sodium; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; 7: |Suzuki-Miyaura Coupling / 9: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2015.11.009