[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

Base Information

Chemical Name:[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid
CAS No.:1155877-11-4
Molecular Formula:C₂₁H₁₈ClFN₂O₃
Molecular Weight:400.837
Hs Code.:

Synonyms:[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

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Chemical Property of [5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

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Technology Process of [5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

There total 1 articles about [5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1155878-01-5
{acetyl-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-amino}-acetic acid methyl ester

: 1155877-11-4
[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

Guidance literature:: {acetyl-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-amino}-acetic acid methyl ester; With lithium hydroxide; water; In methanol; at 20 ℃; for 48h;

With hydrogenchloride; In methanol; water; pH=1 - 2;

Reference yield: 50.0%

: 1155877-11-4
[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

: 109-90-0
ethyl isocyanate

: 1155877-12-5
{1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-3-ethyl-ureido}-acetic acid

Guidance literature:: [5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid; ethyl isocyanate; With pyridine; at 20 ℃; for 48h;

With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water; pH=1;

Reference yield: 22.0%

: 1118-02-1
trimethylsilyl isocyanate

: 1155877-11-4
[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid

: 1155877-13-6
{1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-ureido}-acetic acid

Guidance literature:: trimethylsilyl isocyanate; [5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-ylamino]-acetic acid; With pyridine; at 20 ℃; for 48h;

With water; sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 24h;

With hydrogenchloride; In 1,4-dioxane; water; pH=1;