1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

Base Information

Chemical Name:1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one
CAS No.:1382995-07-4
Molecular Formula:C₁₉H₂₀ClFN₂O
Molecular Weight:346.832
Hs Code.:

Synonyms:1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

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Chemical Property of 1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

Chemical Property:

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Technology Process of 1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

There total 6 articles about 1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-06-3
1-(6-acetyl-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl)pyrrolidin-2-one

: 1382995-07-4
1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

Guidance literature:: With methanol; ammonium acetate; sodium cyanoborohydride; In acetonitrile; at 65 ℃; Sealed tube;

Reference yield:

: 288401-07-0
1-(5-chloro-2-hydroxy-4-methyl-3-nitrophenyl)ethan-1-one

: 1382995-07-4
1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

3.1: hydrogen / platinum on carbon / methanol

4.1: dmap / tetrahydrofuran / 1 h / 20 °C

4.2: 2 h / 20 °C

5.1: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

With methanol; dmap; ammonium acetate; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on carbon; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 685892-19-7
1-(5-chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone

: 1382995-07-4
1-[6-(1-aminoethyl)-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / -78 - 0 °C

1.2: 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / -78 - 20 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 2 h / 80 °C / Inert atmosphere

4.1: hydrogen / platinum on carbon / methanol

5.1: dmap / tetrahydrofuran / 1 h / 20 °C

5.2: 2 h / 20 °C

6.1: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

With methanol; dmap; ammonium acetate; hydrogen; boron tribromide; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; platinum on carbon; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;