tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate
CAS No.:1372187-48-8
Molecular Formula:C₂₁H₂₉Cl₂NO₅
Molecular Weight:446.371
Hs Code.:

Synonyms:tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

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Technology Process of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

There total 12 articles about tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-47-7
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]-1,4-oxazepane-4-carboxylate

: 1372187-48-8
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: With hydrogen; platinum on activated charcoal; In methanol; for 1h; Inert atmosphere;

Reference yield:

: 1372187-01-3
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-formyl-1,4-oxazepane-4-carboxylate

: 1372187-48-8
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.33 h

2: hydrogen / platinum on activated charcoal / methanol / 1 h / Inert atmosphere

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; platinum on activated charcoal; In methanol; acetonitrile;

Reference yield:

: methyl 2-[(3,4-dichlorophenyl)(hydroxy)methyl]prop-2-enoate

: 1372187-48-8
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(3-ethoxy-3-oxopropyl)-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / methanol / 72 h / 10 - 35 °C

2.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

2.2: 0.5 h

3.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

4.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

5.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

6.2: 2 h / -78 - 35 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

7.2: 18 h / 80 °C

7.3: 2 h / 35 °C / Cooling with ice

8.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

9.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice

10.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.33 h

11.1: hydrogen / platinum on activated charcoal / methanol / 1 h / Inert atmosphere

With 1H-imidazole; aluminum (III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; hydrogen; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; calcium chloride; sodium t-butanolate; platinum on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; acetonitrile;