trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

Base Information

Chemical Name:trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide
CAS No.:1539311-26-6
Molecular Formula:C₆₃H₇₂N₄O₉S₂
Molecular Weight:1093.42
Hs Code.:

Synonyms:trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

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Chemical Property of trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

Chemical Property:

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Technology Process of trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

There total 8 articles about trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.4%

: methyl γ-L-glutamyl-L-glutamate

: 7,10-diaza-9-oxo-7-[2-((triphenylmethyl)thio)-ethyl]-12-[(triphenyl-methyl)thio]dodecanoic acid

: 1539311-26-6
trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In chloroform; at 20 ℃; for 48h;

Reference yield:

: 1095-85-8
2-amino tritylthio ethane

: 1539311-26-6
trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 48 h / Reflux

2: sodium hydroxide / acetonitrile / Reflux

3: potassium hydroxide / methanol / 20 °C

4: triethylamine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / chloroform / 48 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; chloroform; acetonitrile;

Reference yield:

: 76-84-6
triphenylmethyl alcohol

: 1539311-26-6
trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / chloroform / Reflux

1.2: 4 h / Reflux

2.1: triethylamine / dichloromethane / 48 h / Reflux

3.1: sodium hydroxide / acetonitrile / Reflux

4.1: potassium hydroxide / methanol / 20 °C

5.1: triethylamine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / chloroform / 48 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; chloroform; acetonitrile;