tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate
CAS No.:1262008-74-1
Molecular Formula:C₂₉H₃₀N₄O₅
Molecular Weight:514.581
Hs Code.:

Synonyms:tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

There total 8 articles about tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1262008-73-0
tert-butyl 2-(8-(N'-hydroxycarbamimidoyl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-74-1
tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In 1,4-dioxane; ethyl acetate; at 100 ℃; for 1.5h; microwave irradiation;

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate

: 1262008-74-1
tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 80 °C / sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: cesium fluoride / tetrahydrofuran / 100 °C / sealed tube

4: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

5: triethylamine / dichloromethane; acetonitrile / 3 h / 0 - 20 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 2 h / 130 °C / microwave irradiation

7: hydroxylamine / ethanol; water / 3 h / 70 °C / microwave irradiation

8: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; 1,4-dioxane / 1.5 h / 100 °C / microwave irradiation

With tetrabutyl ammonium fluoride; hydroxylamine; ammonium formate; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1262008-52-5
tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-74-1
tert-butyl 2-(8-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

2: triethylamine / dichloromethane; acetonitrile / 3 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 2 h / 130 °C / microwave irradiation

4: hydroxylamine / ethanol; water / 3 h / 70 °C / microwave irradiation

5: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; 1,4-dioxane / 1.5 h / 100 °C / microwave irradiation

With hydroxylamine; ammonium formate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20 % Pd(OH)2/C; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;