1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate

Base Information

• Chemical Name: 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate
• CAS No.: 139678-43-6
• Molecular Formula: C₁₈H₁₆BF₂NO₈
• Molecular Weight: 423.135
• Mol file: 139678-43-6.mol

Synonyms:1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate

Chemical Property of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate

There total 1 articles about 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triacetoxyborane (4887-24-5) + ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate (112811-71-9) → 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate (139678-43-6)

Guidance literature:

at 70 - 115 ℃; for 1.5h; Temperature;

Reference yield: 89.1%

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate (139678-43-6) + (1S,6S)-2,8-diazabicyclo[4.3.0]nonane (151213-40-0,158060-81-2,169533-56-6) → moxifloxacin hydrochloride (186826-86-8,1246654-75-0,1346603-25-5)

Guidance literature:

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O₃,O⁴)bis(acyloxy-O)borate; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane; With triethylamine; In acetonitrile; at 15 ℃;

With hydrogenchloride; In water; pH=0.5; Temperature;

Reference yield: 39.0%

1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid (O3,O4)bis(acyloxy-O)borate (139678-43-6) + (R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine (214273-19-5,214273-18-4) → (S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid (133762-22-8)

Guidance literature:

With triethylamine;

DOI:10.1016/S0960-894X(98)00390-4

upstream raw materials:

triacetoxyborane

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Downstream raw materials:

(S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid

moxifloxacin hydrochloride