(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

Base Information

Chemical Name:(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one
CAS No.:138723-49-6
Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Hs Code.:

Synonyms:(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

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Chemical Property of (S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

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Technology Process of (S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

There total 8 articles about (S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 138723-48-5
(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-4-oxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid methyl ester

: 138723-49-6
(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: With lithium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 6.5h;
DOI:10.1021/ja00031a039

Reference yield:

: 134772-94-4
(S)-2-tert-butyl-1-carbomethoxy-3-propionyl-2,3-dihydro-4(1H)-pyrimidinone

: 138723-49-6
(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hexamethyldisilylamide / 1.) THF, -78 deg C, 2.5 h, 2.) THF, -23 deg C, 4 h

2: aq. NaOH / methanol / 0.67 h / 4 °C

3: 1.) 30percent aq. H₂O₂, aq. LiOH, 2.) methyl chloroformate / 1.) THF, 30 min, 2.) THF, RT, 4 h

4: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h, 2.) THF, RT, overnight

5: 62 percent / LiI / dimethylformamide / 6.5 h / 100 °C

With lithium hydroxide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; hexamethyldisilazide; methyl chloroformate; lithium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja00031a039

Reference yield:

: 138723-66-7
(2R)-2-tert-butyl-3-<(S)-2-methyl-3-phenylpropionyl>-2,3-dihydro-4(1H)-pyrimidinone

: 138723-49-6
(S)-2-tert-Butyl-3-((S)-2-methoxy-2-phenyl-acetyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 30percent aq. H₂O₂, aq. LiOH, 2.) methyl chloroformate / 1.) THF, 30 min, 2.) THF, RT, 4 h

2: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h, 2.) THF, RT, overnight

3: 62 percent / LiI / dimethylformamide / 6.5 h / 100 °C

With lithium hydroxide; n-butyllithium; dihydrogen peroxide; methyl chloroformate; lithium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/ja00031a039