D-Leucine-15N

Base Information

• Chemical Name: D-Leucine-15N
• CAS No.: 287484-39-3
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 135.158
• DSSTox Substance ID: DTXSID40439512
• Wikidata: Q82255473
• Mol file: 287484-39-3.mol

Synonyms:D-Leucine-15N;287484-39-3;(2R)-2-(15N)azanyl-4-methylpentanoic acid;DTXSID40439512;D-Leucine-15N, 98 atom % 15N

Chemical Property of D-Leucine-15N

Chemical Property:

• Melting Point: >300 °C(lit.)
• PSA: 63.32000
• LogP: 1.14470
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 132.091663551
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

95% by HPLC; 98% atom 15N ^*data from raw suppliers

D-LEUCINE-15N 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)N
• Isomeric SMILES: CC(C)C[C@H](C(=O)O)[15NH2]

Technology Process of D-Leucine-15N

There total 49 articles about D-Leucine-15N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-leucine-1-13C,15N (80134-83-4,287484-39-3,82152-60-1,82152-65-6) → L-leucine-1-13C,15N,18O (287484-39-3,82152-60-1,82152-65-6)

Guidance literature:

With hydrogenchloride; ¹⁸O-water; at 65 ℃; for 4h; pH=1;

DOI:10.1007/s13361-014-1012-y

Reference yield: 95.0%

sodium 4-methyl-2-oxovalerate (4502-00-5) → <(15)N>-L-leucine (59935-31-8,287484-39-3)

Guidance literature:

With formate dehydrogenase; 1,4-dihydronicotinamide adenine dinucleotide; ¹⁵N-ammonium formate; leucine dehydrogenase; diothiothreitol; Ambient temperature; TRIS, pH=6.5-7.0, 0.1M HCl;

DOI:10.1016/S0040-4039(00)78265-7

Reference yield: 73.0%

C9(12)C(13)C5H22(2)H6I(15)NO4 → (2S,3R,4R)-[1,2,3,4,5-13C5;2-15N2;3,5,5,5',5',5'-2H6]leucine (287484-39-3,82152-60-1,87994-88-5,82152-65-6)

Guidance literature:

C₉⁽¹²⁾C⁽¹³⁾C₅H₂₂⁽²⁾H₆I⁽¹⁵⁾NO₄; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h;

With hydrogenchloride; In water; at 130 ℃; for 1h;

upstream raw materials:

sodium 4-methyl-2-oxovalerate

L-leucine-1-¹³C,¹⁵N

DL-[U-²H; ¹⁵N]-glutamic acid

Downstream raw materials:

L-leucine-1-¹³C,¹⁵N,¹⁸O