Technology Process of (E)-3-[(1R,3S)-3-((E)-2-Phenethyloxycarbonyl-vinyl)-cyclopentyl]-acrylic acid phenethyl ester
There total 3 articles about (E)-3-[(1R,3S)-3-((E)-2-Phenethyloxycarbonyl-vinyl)-cyclopentyl]-acrylic acid phenethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenethyl diisopropyl phosphonate;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
cis-cyclopentane-1,3-dicarboxaldehyde;
In
tetrahydrofuran;
at -78 - 4 ℃;
Further stages.;
DOI:10.1021/ja003712y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: aq. K3Fe(CN)6; K2OsO4; quinuclidine / K2CO3 / 2-methyl-propan-2-ol
2.1: aq. NaIO4 / tetrahydrofuran / 0 - 20 °C
3.1: t-BuOK / tetrahydrofuran / 2 h / 0 - 20 °C
3.2: 90 percent / tetrahydrofuran / -78 - 4 °C
With
Quinuclidine; potassium osmate(VI); sodium periodate; potassium tert-butylate; potassium hexacyanoferrate(III);
potassium carbonate;
In
tetrahydrofuran; tert-butyl alcohol;
1.1: Sharpless dihydroxylation / 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ja003712y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aq. NaIO4 / tetrahydrofuran / 0 - 20 °C
2.1: t-BuOK / tetrahydrofuran / 2 h / 0 - 20 °C
2.2: 90 percent / tetrahydrofuran / -78 - 4 °C
With
sodium periodate; potassium tert-butylate;
In
tetrahydrofuran;
2.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ja003712y
