8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Base Information

• Chemical Name: 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
• CAS No.: 1364195-45-8
• Molecular Formula: C₁₉H₁₇ClN₄O
• Molecular Weight: 352.823
• Mol file: 1364195-45-8.mol

Synonyms:8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Chemical Property of 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

There total 2 articles about 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-methoxybenzoic hydrazide (5785-06-8) + 7-chloro-5-ethyl-1H-benzo[e][1,4]diazepine-2(3H)-thione (1364195-36-7) → 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (1364195-45-8)

Guidance literature:

In butan-1-ol; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.10.080

Reference yield:

7-chloro-5-ethyl-1H-benzo[e][1,4]diazepin-2(3H)-one (1784-60-7) → 8-chloro-6-ethyl-1-(3-methoxyphenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (1364195-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2: butan-1-ol / 24 h / 130 °C / Inert atmosphere

With Lawessons reagent; In tetrahydrofuran; butan-1-ol;

DOI:10.1016/j.bmc.2011.10.080

upstream raw materials:

3-methoxybenzoic hydrazide

7-chloro-5-ethyl-1H-benzo[e][1,4]diazepine-2(3H)-thione

7-chloro-5-ethyl-1H-benzo[e][1,4]diazepin-2(3H)-one