Technology Process of 2'-chloro-5'-bromomethylfluorescein di-t-butyldimethylsilyl ether
There total 1 articles about 2'-chloro-5'-bromomethylfluorescein di-t-butyldimethylsilyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: AlCl3 / nitrobenzene / 0 - 120 °C
1.2: 48.9 percent / 0.1 M HCl / hexane
2.1: ZnCl2 / 1.08 h / 150 - 250 °C
2.2: 90 percent / 3 M HCl / 0.5 h / Heating
3.1: 37 percent Spectr. / imidazole / dimethylformamide / 12 h / 20 °C
4.1: 73.3 percent / 1,3-dibromo-5,5-dimethylhydantoin; 1,1'-azobis(cyclohexanecarbonitrile); AcOH / chlorobenzene / 60 h / 40 °C
With
1H-imidazole; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid; 1,1'-azobis(1-cyanocyclohexanenitrile);
aluminium trichloride; zinc(II) chloride;
In
nitrobenzene; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/ja0287377
- Guidance literature:
-
2'-chloro-5'-bromomethylfluorescein di-t-butyldimethylsilyl ether;
With
pyridine; silver nitrate;
In
acetonitrile;
for 15h;
2-(bis(2-pyridylmethyl)aminomethyl)aniline;
In
acetonitrile;
at 20 ℃;
for 12h;
Further stages.;
DOI:10.1021/ja0287377
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: AgNO3; pyridine / acetonitrile / 15 h
1.2: acetonitrile / 12 h / 20 °C
2.1: 30 percent / AcOH; TBAF / tetrahydrofuran / 36 h / 20 °C
With
pyridine; tetrabutyl ammonium fluoride; silver nitrate; acetic acid;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/ja0287377
