5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Base Information

Chemical Name:5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride
CAS No.:865878-65-5
Molecular Formula:C₂₁H₂₆ClN₃O₃S₂
Molecular Weight:468.041
Hs Code.:

5-[3-(4-<i>tert</i>-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Synonyms:5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

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Chemical Property of 5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Chemical Property:

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Technology Process of 5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

There total 6 articles about 5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77317-55-6
methyl 2-amino-5-iodobenzoate

: 865878-65-5
5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 1 h / 20 °C

2: Pd(PPh₃)4 / dimethylformamide / 1.5 h / 80 °C

3: H₂; aq. HCl / Pd/C / methanol / 1 h

4: Et₃N / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

5: 94 percent / aq. LiOH / acetone / 5 h / 20 °C

6: oxalyl chloride / benzene / 2 h / Heating

With pyridine; hydrogenchloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm0502790

Reference yield:

: 390360-79-9
methyl 5-iodo-2-(methylsulfonamido)benzoate

: 865878-65-5
5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(PPh₃)4 / dimethylformamide / 1.5 h / 80 °C

2: H₂; aq. HCl / Pd/C / methanol / 1 h

3: Et₃N / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

4: 94 percent / aq. LiOH / acetone / 5 h / 20 °C

5: oxalyl chloride / benzene / 2 h / Heating

With hydrogenchloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm0502790

Reference yield:

: 865878-59-7
methyl 5-cyano-2-(methylsulfonamido)benzoate

: 865878-65-5
5-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-2-methanesulfonylamino-benzoyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: H₂; aq. HCl / Pd/C / methanol / 1 h

2: Et₃N / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

3: 94 percent / aq. LiOH / acetone / 5 h / 20 °C

4: oxalyl chloride / benzene / 2 h / Heating

With hydrogenchloride; lithium hydroxide; oxalyl dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/jm0502790