(1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: (1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester
• CAS No.: 154495-66-6
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.389
• Mol file: 154495-66-6.mol

Synonyms:(1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester

Chemical Property of (1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Ethyl2-(1-benzyl-4-(nitromethyl)piperidin-4-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of (1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester

There total 1 articles about (1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

nitromethane (75-52-5) + ethyl 2-(1-benzylpiperidine-4-ylidene)acetate (40110-55-2) → (1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester (154495-66-6)

Guidance literature:

With 1,1,3,3-tetramethylguanidine; for 336h; Ambient temperature;

DOI:10.1002/jhet.5570300529

Reference yield: 25.0%

(1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester (154495-66-6) → 8-Benzyl-2,8-diaza-spiro[4.5]decan-3-one (154495-69-9) + 8-Benzyl-2-hydroxy-2,8-diaza-spiro[4.5]decan-3-one

Guidance literature:

With hydrogen; Adam’s catalyst; In ethanol;

DOI:10.1002/jhet.5570300529

Reference yield:

(1-Benzyl-4-nitromethyl-piperidin-4-yl)-acetic acid ethyl ester (154495-66-6) → 2,8-dibezyl-2,8-diazaspiro<4.5>decan-3-one

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / H₂ / Pt₂O / ethanol

2: 1.) sodium hydride / 1.) DMF, 30 min, 2.) DMF, RT, overnight

With hydrogen; sodium hydride; Adam’s catalyst; In ethanol;

DOI:10.1002/jhet.5570300529

upstream raw materials:

nitromethane

ethyl 2-(1-benzylpiperidine-4-ylidene)acetate

Downstream raw materials:

8-Benzyl-2,8-diaza-spiro[4.5]decan-3-one

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