3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2

Base Information

• Chemical Name: 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2
• CAS No.: 179461-40-6
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 179461-40-6.mol

Synonyms:3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2

Chemical Property of 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2

There total 3 articles about 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Acetic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-4,5-dihydro-isoxazol-5-yl ester (179461-35-9) → 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2 (179461-40-6)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Heating;

DOI:10.1007/BF01433983

Reference yield:

3,5-di-tert-butyl-4-hydroxybenzaldehyde oxime (787-13-3) → 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2 (179461-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-chlorosuccinimide, 2.) Et₃N / 1.) DMF, 40 deg C, 1 h, 2.) 20 deg C, 1 h

2: 93 percent / aq. KOH / methanol / 1 h / Heating

With potassium hydroxide; N-chloro-succinimide; triethylamine; In methanol;

DOI:10.1007/BF01433983

Reference yield:

3,5-di-t-butyl-4-hydroxybenzaldehyde (1620-98-0) → 3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-5-hydroxyisoxazoline-2 (179461-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 85.6 percent / NH₂OH*HCl

2: 1.) N-chlorosuccinimide, 2.) Et₃N / 1.) DMF, 40 deg C, 1 h, 2.) 20 deg C, 1 h

3: 93 percent / aq. KOH / methanol / 1 h / Heating

With potassium hydroxide; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In methanol;

DOI:10.1007/BF01433983

upstream raw materials:

Acetic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-4,5-dihydro-isoxazol-5-yl ester

3,5-di-tert-butyl-4-hydroxybenzaldehyde oxime

3,5-di-t-butyl-4-hydroxybenzaldehyde