methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

Base Information

Chemical Name:methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate
CAS No.:1364538-69-1
Molecular Formula:C₂₄H₂₂N₂O₇
Molecular Weight:450.448
Hs Code.:

Synonyms:methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

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Chemical Property of methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

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Technology Process of methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

There total 3 articles about methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 113496-11-0
[3-(methoxycarbonyl)phenoxy]acetic acid

: 496837-94-6
5-(benzyloxy)-N-methyl-2-nitroaniline

: 1364538-69-1
methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In N,N-dimethyl acetamide; at 10 - 30 ℃; for 3h; Solvent; Inert atmosphere;

Reference yield:

: 1286249-21-5
methyl 3-(chlorocarbonylmethoxy)benzoate

: 496837-94-6
5-(benzyloxy)-N-methyl-2-nitroaniline

: 1364538-69-1
methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

Guidance literature:: 5-(benzyloxy)-N-methyl-2-nitroaniline; With sodium hydride; In tetrahydrofuran; at 0 - 5 ℃; for 0.0833333h; Inert atmosphere;

methyl 3-(chlorocarbonylmethoxy)benzoate; In tetrahydrofuran; at 20 - 30 ℃; for 12h; Reagent/catalyst; Inert atmosphere;

Reference yield:

: 113496-11-0
[3-(methoxycarbonyl)phenoxy]acetic acid

: 1364538-69-1
methyl 3-(2-{[5-(benzyloxy)-2-nitrophenyl](methyl)amino}-2-oxoethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 3 h / 20 - 50 °C

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 - 5 °C / Inert atmosphere

2.2: 12 h / 20 - 30 °C / Inert atmosphere

With thionyl chloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;