5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:170647-92-4
Molecular Formula:C₃₇H₄₆ClFN₄O₃S₃
Molecular Weight:745.447
Hs Code.:

Synonyms:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 9 articles about 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 170647-92-4
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 2 h, 2.) DMF, 50 deg C, 3 h

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; In tetrachloromethane; ethanol;
DOI:10.1021/jm00019a004

Reference yield:

: 25017-08-7
1-(4-chlorophenyl)pentan-1-one

: 170647-92-4
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid / 0.5 h / 0 °C

2: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

3: 80 percent / SnCl₂*2H₂O, conc. HCl / tetrahydrofuran / Ambient temperature

4: 1.) Conc_. HCl, NaNO₂, 2.) SnCl₂*2H₂O, conc. HCl / 1.) THF, 0 deg C, 1 h, 2.) THF, 5 deg C, overnight

5: 2.) Et₃N / 1.) toluene, 50 deg C, 2 h, 2.) toluene, 90 deg C, 16 h

6: 1.) NaH / 1.) DMF, 50 deg C, 2 h, 2.) DMF, 50 deg C, 3 h

With hydrogenchloride; boron trifluoride diethyl etherate; nitric acid; sodium hydride; triethylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00019a004

Reference yield:

: 66353-29-5
4-chloro-3-nitrovalerophenone

: 170647-92-4
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

2: 80 percent / SnCl₂*2H₂O, conc. HCl / tetrahydrofuran / Ambient temperature

3: 1.) Conc_. HCl, NaNO₂, 2.) SnCl₂*2H₂O, conc. HCl / 1.) THF, 0 deg C, 1 h, 2.) THF, 5 deg C, overnight

4: 2.) Et₃N / 1.) toluene, 50 deg C, 2 h, 2.) toluene, 90 deg C, 16 h

5: 1.) NaH / 1.) DMF, 50 deg C, 2 h, 2.) DMF, 50 deg C, 3 h

With hydrogenchloride; boron trifluoride diethyl etherate; sodium hydride; triethylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00019a004