[5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

Base Information

Chemical Name:[5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester
CAS No.:1174376-23-8
Molecular Formula:C₁₅H₁₈F₂N₃O₄P
Molecular Weight:373.296
Hs Code.:

Synonyms:[5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

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Chemical Property of [5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

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Technology Process of [5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

There total 2 articles about [5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1174376-11-4
5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4 amine

: 814-49-3
diethyl chlorophosphate

: 1174376-23-8
[5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 1174376-23-8
[5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-yl]phosphoramidic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane / 0.17 h

1.2: 20 - 120 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; 1,4-dioxane;