(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
CAS No.:1283143-23-6
Molecular Formula:C₂HF₃O₂*C₁₈H₁₈BrNO₃
Molecular Weight:490.274
Hs Code.:

Synonyms:(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Chemical Property of (S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Technology Process of (S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 7 articles about (S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1283146-85-9
(S)-methyl 2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetate

: 76-05-1
trifluoroacetic acid

: 1283143-23-6
(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: (S)-methyl 2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetate; With water; lithium hydroxide; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 19h;

With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; at 0 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 1283143-23-6
(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 90 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: dimethyl sulfoxide / 4 h / 50 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5.1: hydrogenchloride / methanol; dichloromethane / 0 - 20 °C

6.1: pyridine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran; isopropyl alcohol / 19 h / 20 °C

7.2: 0 °C

With pyridine; hydrogenchloride; water; hydrogen; triethylamine; sodium hydroxide; lithium hydroxide; copper(l) iodide; palladium 10% on activated carbon; copper diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1283147-14-7
(S)-2-(1-(4-hydroxyphenyl)pyrrolidin-2-yl)acetonitrile

: 1283143-23-6
(S)-2-(1-(4-(3-bromophenoxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; dichloromethane / 0 - 20 °C

2.1: pyridine / copper diacetate / dichloromethane / 24 h / 20 °C / Molecular sieve; Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran; isopropyl alcohol / 19 h / 20 °C

3.2: 0 °C

With pyridine; hydrogenchloride; water; lithium hydroxide; copper diacetate; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;