1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Base Information

Chemical Name:1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate
CAS No.:134394-98-2
Molecular Formula:C₃₇H₄₁FN₂O₅
Molecular Weight:612.741
Hs Code.:

Synonyms:1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Suppliers and Price of 1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-OxoAtorvastatintert-ButylEster
1mg
$ 210.00

Medical Isotopes, Inc.
3-OxoAtorvastatintert-ButylEster
1 mg
$ 700.00

Total 6 raw suppliers

Chemical Property of 1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

3-OxoAtorvastatintert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Oxo Atorvastatin tert-Butyl Ester is a Boc-protected oxo-derivative of Atorvastatin (A791750, Ca Salt); a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin can also lower both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.

Technology Process of 1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

There total 7 articles about 1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887324-52-9,110862-48-1
Atorvastatin

: 40052-13-9
mono-tert-butyl malonate

: 134394-98-2
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Guidance literature:: Atorvastatin; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 3h;

mono-tert-butyl malonate; With magnesium ethylate; at 20 ℃; for 20h;

Reference yield:

: 864408-78-6
(R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid

: 40052-13-9
mono-tert-butyl malonate

: 134394-98-2
1,1-dimethylethyl (R)-7-<2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-<(phenylamino)carbonyl>-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-1-heptanoate

Guidance literature:: (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 3h;

mono-tert-butyl malonate; With magnesium ethylate; In tetrahydrofuran; at 20 ℃; for 20h;