6-Bromo-2-chloroquinoline-4-carboxylic acid

Base Information

Chemical Name:6-Bromo-2-chloroquinoline-4-carboxylic acid
CAS No.:287176-62-9
Molecular Formula:C₁₀H₅BrClNO₂
Molecular Weight:286.512
Hs Code.:
DSSTox Substance ID:DTXSID50383456
Wikidata:Q82175169
Mol file:287176-62-9.mol

Synonyms:6-bromo-2-chloroquinoline-4-carboxylic acid;287176-62-9;6-bromo-2-chloro-quinoline-4-carboxylic Acid;DTXSID50383456;AMY20966;BCP33160;BBL022030;MFCD00106420;STK894749;AKOS000320407;SB71891;BS-22208;CS-0199388;FT-0620973;F73418;6-Bromo-2-chloroquinoline-4-carboxylic acid,97;A929672;6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97

Suppliers and Price of 6-Bromo-2-chloroquinoline-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Bromo-2-chloroquinoline-4-carboxylicacid 97%
1g
$ 357.00

Chemenu
6-Bromo-2-chloroquinoline-4-carboxylicacid 97%
1g
$ 338.00

American Custom Chemicals Corporation
6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 95.00%
1G
$ 826.37

Total 8 raw suppliers

Chemical Property of 6-Bromo-2-chloroquinoline-4-carboxylic acid

Chemical Property:

Melting Point:200℃
Boiling Point:421.0±40.0 °C(Predicted)
PKA:1.96±0.30(Predicted)
PSA：50.19000
Density:1.819±0.06 g/cm3(Predicted)
LogP:3.34890
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:284.91922
Heavy Atom Count:15
Complexity:264

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2-chloroquinoline-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.;
Hazard Codes: Xi:Irritant;
Statements: R36/37/38:Irritating to eyes, respiratory system and skin.;
Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Br)C(=CC(=N2)Cl)C(=O)O

Technology Process of 6-Bromo-2-chloroquinoline-4-carboxylic acid

There total 1 articles about 6-Bromo-2-chloroquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5463-29-6
6-bromo-2-hydroxyquinoline-4-carboxylic acid

: 287176-62-9
6-bromo-2-chloro-4-quinolinecarboxylic acid

Guidance literature:: With trichlorophosphate; for 2h; Reflux;
DOI:10.1021/acs.jmedchem.6b00034

Reference yield:

: 287176-62-9
6-bromo-2-chloro-4-quinolinecarboxylic acid

: ethyl 5-[benzyl(methyl)carbamoyl]-7-bromoimidazo[1,5-a]quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00034

Reference yield:

: 287176-62-9
6-bromo-2-chloro-4-quinolinecarboxylic acid

: ethyl 5-[benzyl(methyl)carbamoyl]-7-[(trimethylsilyl)ethynyl]imidazo[1,5-a]quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere

4: triethylamine; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾ / 20 °C / Reflux

With thionyl chloride; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 4: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.6b00034