(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

Base Information

Chemical Name:(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol
CAS No.:725230-51-3
Molecular Formula:C₂₂H₃₈O₃Si
Molecular Weight:378.627
Hs Code.:

Synonyms:(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

Suppliers and Price of (E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

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Chemical Property of (E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

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Technology Process of (E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

There total 5 articles about (E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 725230-52-4
triisopropyl[4-methoxy-3-methyl-5-(3-methybut-2-enyl)phenyloxy]-silane

: 725230-51-3
(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

Guidance literature:: triisopropyl[4-methoxy-3-methyl-5-(3-methybut-2-enyl)phenyloxy]-silane; With selenium(IV) oxide; In 1,4-dioxane; water; at 100 ℃; for 1h;

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.200300767

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 725230-51-3
(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / imidazole / dimethylformamide / 18 h / 20 °C

2.1: 10.7 g / potassium carbonate / acetone / 4 h / Heating

3.1: PhLi / dibutyl ether; cyclohexane / 1 h / 20 °C

3.2: 91 percent / DMPU / diethyl ether; cyclohexane / 12 h / 20 °C

4.1: selenium dioxide / dioxane; H₂O / 1 h / 100 °C

4.2: 60 percent / sodium borohydride / ethanol / 0.5 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; potassium carbonate; phenyllithium; In 1,4-dioxane; dibutyl ether; cyclohexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ejoc.200300767

Reference yield:

: 50848-60-7
2-bromo-6-methylbenzene-1,4-diol

: 725230-51-3
(E)-4-[2-methoxy-3-methyl-5-(triisopropylsilyloxy)phenyl]-2-methylbut-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / imidazole / dimethylformamide / 18 h / 20 °C

2.1: 10.7 g / potassium carbonate / acetone / 4 h / Heating

3.1: PhLi / dibutyl ether; cyclohexane / 1 h / 20 °C

3.2: 91 percent / DMPU / diethyl ether; cyclohexane / 12 h / 20 °C

4.1: selenium dioxide / dioxane; H₂O / 1 h / 100 °C

4.2: 60 percent / sodium borohydride / ethanol / 0.5 h / 20 °C

With 1H-imidazole; selenium(IV) oxide; potassium carbonate; phenyllithium; In 1,4-dioxane; dibutyl ether; cyclohexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ejoc.200300767