3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

Base Information

Chemical Name:3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate
CAS No.:174728-19-9
Molecular Formula:C₂₀H₂₄N₂O₅S₂
Molecular Weight:436.553
Hs Code.:

Synonyms:3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

Chemical Property:

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Technology Process of 3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

There total 6 articles about 3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 151140-65-7
C-[3-(3-hydroxypropyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide

: 174728-19-9
3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

Guidance literature:: With hydrogenchloride; sodium hydroxide; In pyridine; water;

Reference yield:

: 4124-41-8
p-toluenesulfonylanhydride

: 151140-65-7
C-[3-(3-hydroxypropyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide

: 174728-19-9
3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

Guidance literature:: With dmap; In pyridine; at 0 - 5 ℃; for 1h;
DOI:10.1021/jo971368q

Reference yield:

: 694-54-2
tetrahydro-2H-2-pyranol

: 174728-19-9
3-[5-[[(methylamino)sulfonyl]methyl]-1H-indol-3-yl]propyl p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOH, 2.) H₃PO₄ / 1.) EtOH, H₂O, pH 3.5, 60 deg C, 3 h, 2.) DCE, reflux, 1.5 h

2: 6.05 g / DMAP / pyridine / 1 h / 0 - 5 °C

With dmap; sodium hydroxide; phosphoric acid; In pyridine;
DOI:10.1021/jo971368q